DIGIPREDICT brings together three members from academia, two large R&D institutes, two hospitals, two high-tech SMEs and a management and communication SME from five European countries.
Between them, they address all the key challenges of the project by covering a wide range of disciplines including informatics (machine learning), engineering (embedded systems, sensors and wearables), medical science (organ-on-chip systems, digital medicine), translational science (clinical studies and research), ethical and regulatory frameworks. All consortium members have outstanding records of scientific excellence, from early and experienced post-docs to several young group leaders and to well-established leaders of large research groups.
DIGIPREDICT is a direct offspring of the thriving community created around the Health EU FET Flagship initiative and initiated by the Health EU board members EPFL, UTWENTE, ETHZ, and Charité. Hence, DIGIPREDICT can reach out to the established network of the Health EU initiative, grouping 110 partners and additional 80 stakeholders from large industries, patient and professional organizations, hospitals, insurance companies, regulatory bodies and innovative SME’s and investors.
Nanoelectronic Devices Laboratory (NANOLAB) : silicon micro/nano‐electronics with special emphasis on the technology, design and modeling of low power nanoscale solid‐state devices and sensors and their integration into smart micro/nano‐systems. Embedded Systems Laboratory (ESL): system-level multi-objective design methods, optimization methodologies and tools for high-performance embedded systems and nano-scale Multi-Processor System-on-Chip (MPSoC) architectures targeting the Internet-of-Things (IoT) Era.
Machine Learning and Optimization Laboratory (MLO) ML on the edge Laboratory of Movement Analysis and Measurement (LMAM) wearable systems and algorithms for movement/activity detection and characterization, and interaction between long term activity and physiological time-series.
In addition, the EPFL Center for Intelligent Systems (CIS) provides its expertise to connect and support the scientific dimension of the project.
Development of Heart-on-Chip and Vessel-on-Chip models, two types of OoC, by integrating human stem cell-derived heart tissues and vascular tissues in microfluidic chips
ETH Zurich will evaluate physiological low power sensors for example for measuring the core body temperature and respiration rate, and explore a eudermic ultra-low power and miniaturized CNT sensor for high sensitivity axial strain measurement during respiratory activity to monitor the respiration rate.
Implementation of CMOS-based microelectrode array (MEA) chips with design and fabricate a new type of chip consisting of flexible mesh-like electrode arrays to serve as a barrier measurement device for heart-on-chip and vasculature-on-chip.
Development of a custom chip for the readout of novel biormarker sensors with integration and readout into the electronics core of a novel biomarker wearable.
Development of a system to collect and transfer data in a form factor of a wearable sensing physiological (respiration-related) information.
Contribute to the project management and dissemination activities.
The Charité will be engaged in the project with the clinic for cardiothoracic surgery in close collaboration with the German Heart Center Berlin.
Contribution to project management and dissemination activities aimed at a broader audience.
Design and manufacture chips with arrays of ultra-sharp, hollow microneedles in monocrystalline silicon using micro electro mechanical system (MEMS) technology.
Biofunctionalisation of selective biomarker nanosensors; networking, education activities and designing the public acceptance for swift clinical translation of digital twins.